Sparrow Lab

Selected Publications

  1. Ramkumar S, Jastrzebska B, Montenegro D, Sparrow JR, von Lintig J. Unraveling the mystery of ocular retinoid turnover: Insights from albino mice and the role of STRA6. J Biol Chem. 2024 Mar;300(3):105781. doi: 10.1016/j.jbc.2024.105781. Epub 2024 Feb 21. PubMed PMID: 38395306; PubMed Central PMCID: PMC10950888.
  2. Grubaugh CR, Dhingra A, Prakash B, Montenegro D, Sparrow JR, Daniele LL, Curcio CA, Bell BA, Hussain MM, Boesze-Battaglia K. Microsomal triglyceride transfer protein is necessary to maintain lipid homeostasis and retinal function. bioRxiv. 2023 Dec 6;. doi: 10.1101/2023.12.06.570418. PubMed PMID: 38105975; PubMed Central PMCID: PMC10723417.
  3. Parmann R, Tsang SH, Sparrow JR. Primary versus Secondary Elevations in Fundus Autofluorescence. Int J Mol Sci. 2023 Aug 2;24(15). doi: 10.3390/ijms241512327. Review. PubMed PMID: 37569703; PubMed Central PMCID: PMC10419315.
  4. Kim HJ, Zhao J, Walewski JL, Sparrow JR. A high fat diet fosters elevated bisretinoids. J Biol Chem. 2023 Jun;299(6):104784. doi: 10.1016/j.jbc.2023.104784. Epub 2023 May 4. PubMed PMID: 37146972; PubMed Central PMCID: PMC10236470.
  5. Chang YJ, Jenny LA, Li YS, Cui X, Kong Y, Li Y, Sparrow JR, Tsang SH. CRISPR editing demonstrates rs10490924 raised oxidative stress in iPSC-derived retinal cells from patients with ARMS2/HTRA1-related AMD. Proc Natl Acad Sci U S A. 2023 May 9;120(19):e2215005120. doi: 10.1073/pnas.2215005120. Epub 2023 May 1. PubMed PMID: 37126685; PubMed Central PMCID: PMC10175836.
  6. Breazzano MP, Oh JK, Batson SA, Kucherich JA, Karani R, Rohrmann CM, Sparrow JR, Fragiotta S, Tsang SH. Vitamin A deficiency and the retinal "double carrot" sign with optical coherence tomography. Eye (Lond). 2023 May;37(7):1489-1495. doi: 10.1038/s41433-022-02137-9. Epub 2022 Jul 15. PubMed PMID: 35840717; PubMed Central PMCID: PMC10169789.
  7. Greenstein VC, Castillejos DS, Tsang SH, Lee W, Sparrow JR, Allikmets R, Birch DG, Hood DC. Monitoring Lesion Area Progression in Stargardt Disease: A Comparison of En Face Optical Coherence Tomography and Fundus Autofluorescence. Transl Vis Sci Technol. 2023 May 1;12(5):2. doi: 10.1167/tvst.12.5.2. PubMed PMID: 37126335; PubMed Central PMCID: PMC10153573.
  8. Paavo M, Lee W, Parmann R, Lima de Carvalho JR Jr, Zernant J, Tsang SH, Allikmets R, Sparrow JR. Insights Into PROM1-Macular Disease Using Multimodal Imaging. Invest Ophthalmol Vis Sci. 2023 Apr 3;64(4):27. doi: 10.1167/iovs.64.4.27. PubMed PMID: 37093133; PubMed Central PMCID: PMC10148657.
  9. Kong Y, Liu PK, Li Y, Nolan ND, Quinn PMJ, Hsu CW, Jenny LA, Zhao J, Cui X, Chang YJ, Wert KJ, Sparrow JR, Wang NK, Tsang SH. HIF2α activation and mitochondrial deficit due to iron chelation cause retinal atrophy. EMBO Mol Med. 2023 Feb 8;15(2):e16525. doi: 10.15252/emmm.202216525. Epub 2023 Jan 16. PubMed PMID: 36645044; PubMed Central PMCID: PMC9906391.
  10. Montenegro D, Zhao J, Kim HJ, Shmarakov IO, Blaner WS, Sparrow JR. Products of the visual cycle are detected in mice lacking retinol binding protein 4, the only known vitamin A carrier in plasma. J Biol Chem. 2022 Dec;298(12):102722. doi: 10.1016/j.jbc.2022.102722. Epub 2022 Nov 19. PubMed PMID: 36410431; PubMed Central PMCID: PMC9768380.
  11. Kolesnikova M, Lima de Carvalho JR Jr, Parmann R, Kim AH, Mahajan VB, Tsang SH, Sparrow JR. Chorioretinal atrophy following voretigene neparvovec despite the presence of fundus autofluorescence. Mol Genet Genomic Med. 2022 Nov;10(11):e2038. doi: 10.1002/mgg3.2038. Epub 2022 Oct 12. PubMed PMID: 36225124; PubMed Central PMCID: PMC9651599.
  12. Verra DM, Spinnhirny P, Sandu C, Grégoire S, Acar N, Berdeaux O, Brétillon L, Sparrow JR, Hicks D. Intrinsic differences in rod and cone membrane composition: implications for cone degeneration. Graefes Arch Clin Exp Ophthalmol. 2022 Oct;260(10):3131-3148. doi: 10.1007/s00417-022-05684-9. Epub 2022 May 7. Review. PubMed PMID: 35524799; PubMed Central PMCID: PMC9724003.
  13. Kim HJ, Zhao J, Sparrow JR. Vitamin A aldehyde-taurine adducts function in photoreceptor cells. Redox Biol. 2022 Aug;54:102386. doi: 10.1016/j.redox.2022.102386. Epub 2022 Jul 3. PubMed PMID: 35809434; PubMed Central PMCID: PMC9287728.
  14. Cui X, Kim HJ, Cheng CH, Jenny LA, Lima de Carvalho JR, Chang YJ, Kong Y, Hsu CW, Huang IW, Ragi SD, Lin CS, Li X, Sparrow JR, Tsang SH. Long-term vitamin A supplementation in a preclinical mouse model for RhoD190N-associated retinitis pigmentosa. Hum Mol Genet. 2022 Jul 21;31(14):2438-2451. doi: 10.1093/hmg/ddac032. PubMed PMID: 35195241; PubMed Central PMCID: PMC9307315.
  15. Parmann R, Greenstein VC, Tsang SH, Sparrow JR. Choroideremia Carriers: Dark-Adapted Perimetry and Retinal Structures. Invest Ophthalmol Vis Sci. 2022 Jul 8;63(8):4. doi: 10.1167/iovs.63.8.4. PubMed PMID: 35816046; PubMed Central PMCID: PMC9284471.
  16. Oh JK, Vargas Del Valle JG, Lima de Carvalho JR Jr, Sun YJ, Levi SR, Ryu J, Yang J, Nagasaki T, Emanuelli A, Rasool N, Allikmets R, Sparrow JR, Izquierdo NJ, Duncan JL, Mahajan VB, Tsang SH. Expanding the phenotype of TTLL5-associated retinal dystrophy: a case series. Orphanet J Rare Dis. 2022 Apr 1;17(1):146. doi: 10.1186/s13023-022-02295-9. PubMed PMID: 35365235; PubMed Central PMCID: PMC8973795.
  17. Lima de Carvalho JR Jr, Tsang SH, Sparrow JR. VITAMIN A DEFICIENCY MONITORED BY QUANTITATIVE SHORT WAVELENGTH FUNDUS AUTOFLUORESCENCE IN A CASE OF BARIATRIC SURGERY. Retin Cases Brief Rep. 2022 Mar 1;16(2):218-221. doi: 10.1097/ICB.0000000000000931. PubMed PMID: 31599792; PubMed Central PMCID: PMC7182472.
  18. Parmann R, Tsang SH, Zernant J, Allikmets R, Greenstein VC, Sparrow JR. Comparisons Among Optical Coherence Tomography and Fundus Autofluorescence Modalities as Measurements of Atrophy in ABCA4-Associated Disease. Transl Vis Sci Technol. 2022 Jan 3;11(1):36. doi: 10.1167/tvst.11.1.36. PubMed PMID: 35089312; PubMed Central PMCID: PMC8802021.
  19. Liu Y, Bell BA, Song Y, Kim HJ, Sterling JK, Kim BJ, Poli M, Guo M, Zhang K, Rao A, Sparrow JR, Su G, Dunaief JL. Intraocular iron injection induces oxidative stress followed by elements of geographic atrophy and sympathetic ophthalmia. Aging Cell. 2021 Nov;20(11):e13490. doi: 10.1111/acel.13490. Epub 2021 Oct 9. PubMed PMID: 34626070; PubMed Central PMCID: PMC8590099.
  20. Kim HJ, Montenegro D, Zhao J, Sparrow JR. Bisretinoids of the Retina: Photo-Oxidation, Iron-Catalyzed Oxidation, and Disease Consequences. Antioxidants (Basel). 2021 Aug 29;10(9). doi: 10.3390/antiox10091382. Review. PubMed PMID: 34573014; PubMed Central PMCID: PMC8467448.
  21. Arunkumar R, Gorusupudi A, Li B, Blount JD, Nwagbo U, Kim HJ, Sparrow JR, Bernstein PS. Lutein and zeaxanthin reduce A2E and iso-A2E levels and improve visual performance in Abca4(-/-)/Bco2(-/-) double knockout mice. Exp Eye Res. 2021 Aug;209:108680. doi: 10.1016/j.exer.2021.108680. Epub 2021 Jun 20. PubMed PMID: 34161819; PubMed Central PMCID: PMC8595537.
  22. Jauregui R, Parmann R, Nuzbrokh Y, Tsang SH, Sparrow JR. Stage-dependent choriocapillaris impairment in Best vitelliform macular dystrophy characterized by optical coherence tomography angiography. Sci Rep. 2021 Jul 12;11(1):14300. doi: 10.1038/s41598-021-93316-3. PubMed PMID: 34253754; PubMed Central PMCID: PMC8275766.
  23. Nassisi M, Smirnov VM, Solis Hernandez C, Mohand-Saïd S, Condroyer C, Antonio A, Kühlewein L, Kempf M, Kohl S, Wissinger B, Nasser F, Ragi SD, Wang NK, Sparrow JR, Greenstein VC, Michalakis S, Mahroo OA, Ba-Abbad R, Michaelides M, Webster AR, Degli Esposti S, Saffren B, Capasso J, Levin A, Hauswirth WW, Dhaenens CM, Defoort-Dhellemmes S, Tsang SH, Zrenner E, Sahel JA, Petersen-Jones SM, Zeitz C, Audo I. CNGB1-related rod-cone dystrophy: A mutation review and update. Hum Mutat. 2021 Jun;42(6):641-666. doi: 10.1002/humu.24205. Epub 2021 May 16. Review. PubMed PMID: 33847019; PubMed Central PMCID: PMC8218941.
  24. Sparrow JR, Parmann R, Tsang SH, Allikmets R, Chang S, Jauregui R. Shared Features in Retinal Disorders With Involvement of Retinal Pigment Epithelium. Invest Ophthalmol Vis Sci. 2021 Jun 1;62(7):15. doi: 10.1167/iovs.62.7.15. PubMed PMID: 34115091; PubMed Central PMCID: PMC8196415.
  25. Coleman DJ, Lee W, Daly S, Breazzano MP, Sparrow J, Tsang SH. Central serous chorioretinopathy treatment with a systemic PDE5 and PDE6 inhibitor (sildenafil). Am J Ophthalmol Case Rep. 2021 Mar;21:100998. doi: 10.1016/j.ajoc.2020.100998. eCollection 2021 Mar. PubMed PMID: 33364520; PubMed Central PMCID: PMC7750488.
  26. Kim HJ, Sparrow JR. Bisretinoid phospholipid and vitamin A aldehyde: shining a light. J Lipid Res. 2021;62:100042. doi: 10.1194/jlr.TR120000742. Epub 2021 Feb 6. Review. PubMed PMID: 32371567; PubMed Central PMCID: PMC7933493.
  27. Han L, de Carvalho JRL Jr, Parmann R, Tezel TH, Chang S, Sharma T, Sparrow JR. Central Serous Chorioretinopathy Analyzed by Multimodal Imaging. Transl Vis Sci Technol. 2021 Jan;10(1):15. doi: 10.1167/tvst.10.1.15. eCollection 2021 Jan. PubMed PMID: 33510954; PubMed Central PMCID: PMC7804571.
  28. Zhao J, Kim HJ, Ueda K, Zhang K, Montenegro D, Dunaief JL, Sparrow JR. A vicious cycle of bisretinoid formation and oxidation relevant to recessive Stargardt disease. J Biol Chem. 2021 Jan-Jun;296:100259. doi: 10.1016/j.jbc.2021.100259. Epub 2021 Jan 7. PubMed PMID: 33837742; PubMed Central PMCID: PMC7948646.
  29. Jauregui R, Nuzbrokh Y, Su PY, Zernant J, Allikmets R, Tsang SH, Sparrow JR. Retinal Pigment Epithelium Atrophy in Recessive Stargardt Disease as Measured by Short-Wavelength and Near-Infrared Autofluorescence. Transl Vis Sci Technol. 2021 Jan;10(1):3. doi: 10.1167/tvst.10.1.3. eCollection 2021 Jan. PubMed PMID: 33505770; PubMed Central PMCID: PMC7794276.
Complete List of Publications