Precision Ophthalmology

Ophthalmology is a promising specialty for implementing Precision Medicine because of the eye’s amenability to intervention and the significant human and economic burdens it incurs. Retinal degenerations affect 10 million Americans and account for a significant portion of the USA’s annual $51 billion dollar healthcare expenditure on ophthalmology. 

Ophthalmic Precision Medicine is facilitated by the eye’s relative immune privilege and accessibility, and the effects of treatment can be precisely monitored non-invasively at the resolution of a single cell with adaptive optics imaging. As a pair organ, the eye provides the ideal treatment-control conditions and distinguishes itself as the ideal system for Precision Medicine due to the low risk of rejection of gene and stem cell therapies. In fact, therapies involving embryonic stem cell transplants for macular degenerations are the only FDA-approved regenerative medicine trials currently available in the US.

At Columbia University Irving Medical Center, the Edward S. Harkness Eye Institute's clinic has over 800 genotyped retinitis pigmentosa and juvenile macular degeneration patients awaiting FDA approval of gene therapy approaches to restore their ability to conduct activities of daily living.

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Precision Ophthalmology 2025: In Our DNA is from June 12-14, 2025. Join us in New York City for 1, 2, or 3 Days.

Precision Ophthalmology 2025: In Our DNA

Precision Ophthalmology Books

Precision Ophthalmology at Columbia 2017

Cover and inside pages of the Precision Ophthalmology at Columbia book
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Precision Ophthalmology 2020: Applied Genetics

Cover and inside pages of the Precision Ophthalmology 2020: Applied Genetics book.
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