Selected Publications

• Owji AP, Dong J, Kittredge A, Wang J, Zhang Y, Yang T. Neurotransmitter-bound bestrophin channel structures reveal small molecule drug targeting sites for disease treatment. Nat Commun, 2024; 15(1):10766
• Wang J, Owji AP, Kittredge A, Clark, Z, Zhang Y, Yang T. GAD65 tunes the functions of Best1 as a GABA receptor and a neurotransmitter conducting channel. Nat Commun, 2024; 15(1):8051
• Owji AP, Yu K, Kittredge A, Wang J, Zhang Y, Yang T. Bestrophin-2 and glutamine synthetase form a complex for glutamate release. Nature, 2022; 611(7034): 180-187
• Owji AP, Wang J, Kittredge A, Clark Z, Zhang Y, Hendrickson WA, Yang T. Structures and gating mechanisms of human bestrophin anion channels. Nat Commun, 2022; 13(1):3836
• Zhao Q, Kong Y, Kittredge A, Li Y, Shen Y, Zhang Y, Tsang SH, Yang T. Distinct expression requirements and rescue strategies for BEST1 loss- and Gain-of-function mutations. eLife, 2021; 10: e67622
• Owji AP, Zhao Q, Ji C, Kittredge A, Hopiavuori A, Fu Z, Ward N, Clarke OB, Shen Y, Zhang Y, Hendrickson WA, Yang T. Structural and functional characterization of the bestrophin-2 anion channel. Nat Struct Mol Biol, 2020; 27(4): 382-391
• Zhang Y, Kittredge A, Ward N, Ji C, Chen S, Yang T. ATP activates bestrophin ion channels through direct interaction. Nat Commun, 2018; 9(1): 3126
• Li Y, Zhang Y, Xu Y, Kittredge A, Ward N, Chen S, Tsang SH, Yang T. Patient-specific mutations impair BESTROPHIN1’s essential role in mediating Ca²⁺-dependent Cl^- currents in human RPE. eLife, 2017; 6: e29914

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