Mittelbrunn Lab

Principal Investigator

The Mittelbrunn lab has been a pioneer in proposing that the immune system, particularly T cells, controls tissue senescence and the onset of age-related diseases. Her laboratory is conducting research on how the immune system contributes to systemic senescence as well as to the general aging process.

Research Interests

Age-driven deterioration of the adaptive immune system is responsible for high susceptibility to autoimmune diseases, infections and cancer, as well as a decrease in the effectiveness of vaccinations.

Emerging evidence by others and us support that age-associated deterioration of the immune system can also be involved in the increased susceptibility to neurodegenerative, cardiovascular or metabolic diseases. Our research is aim to provide convincing evidence of the potential role of reinvigorating T cells or depleting pathogenic age-associated T cells, not only to prevent immunosenescence, but also to delay inflammaging, systemic senescence and the onset of age-related disorders. Thus, we are uncovering new approaches ranging from nutritional interventions, developing drugs, cell therapy   that would guide strategies for improving immune responses, promoting resilience to age-related diseases, and healthy aging.

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