Maria Mittelbrunn, PhD

  • Visiting Professor at the Columbia Center for Translational Immunology (CCTI) and the Columbia Center for Human Longevity (CCHL)
  • Tenured Researcher, Consejo Superior De Investigaciones Cientificas (CSIC), Spain
Profile Headshot

Overview

Dr. Maria Mittelbrunn is a visiting Professor at the CCTI and CCHL. Dr. Mittelbrunn received the degree of Doctor in Biomedicine, Biochemistry and Molecular Biology from the School of Medicine at the Autonomous University of Madrid in 2006, and performed postdoctoral work at Spanish National Center for Cardiovascular Research (CNIC) (Madrid, Spain) from 2007 to 2016. Since 2017, she is Group Leader of the Immunometabolism & Inflammation Laboratory at the Molecular Biology Center (Madrid). Since 2021, she is Research Scientist of the Spanish Research Council (CSIC).

Academic Appointments

  • Visiting Professor at the Columbia Center for Translational Immunology (CCTI) and the Columbia Center for Human Longevity (CCHL)
  • Tenured Researcher, Consejo Superior De Investigaciones Cientificas (CSIC), Spain

Administrative Titles

  • Principal Investigator, Molecular Biology Center, Madrid, Spain

Languages

  • English
  • Spanish

Credentials & Experience

Education & Training

  • 2006 Biomedicine, Biochemistry and Molecular Biology, School of Medicine at the Autonomous University of Madrid, Spain
  • Fellowship: 2016 Spanish National Center for Cardiovascular Research (CNIC), Madrid, Spain

Honors & Awards

  • 2022: BANCO SABADELL AWARD for Biomedical Research
  • 2015: LÓREAL UNESCO for Women in Science
  • 2006: Doctoral thesis Extraordinary Prize

Research

Among Dr. Maria Mittelbrunn original contributions are the demonstration that the deterioration of immune system function with aging not only compromises the response to infection, cancer, vaccination, or predisposes to autoimmunity but also increases the risk for cardiovascular, metabolic, and cognitive decline, thereby placing the immune system as a controller of healthy aging. Dr. Mittelbrunn has contributed to decoding the molecular mechanisms by which aged T cells contribute to inflammaging and age-related diseases. Additionally, she has proposed new therapeutic targets to delay age-related multimorbidity and to reverse aortic aneurysms, thus preventing sudden death due to aortic dissections.

She has obtained funding from the major European and Spanish funding organizations, including an European Research Council Starting Grant in 2016, and  Consolidator Grant in 2022.

For her scientific achievements, she has been awarded with Doctoral thesis Extraordinary Prize (2006), LÓREAL UNESCO for Women in Science (2015), BANCO SABADELL AWARD for Biomedical Research (2022), and Royal Spanish Academia of Science for young  researchers among others. Since 2024, she is Visiting Professor at Columbia Center for Translational Immunology (CCTI) and Columbia Center for Human Longevity (CCHL).

Selected Publications

  1. Mitochondria during T cell aging.
    Escrig-Larena JI, Delgado-Pulido S, Mittelbrunn M. Semin Immunol. 2023 Sep;69:101808. doi: 10.1016/j.smim.2023.101808. Epub 2023 Jul 18.PMID: 37473558 
  2. Extremely Differentiated T Cell Subsets Contribute to Tissue Deterioration During Aging.
    Soto-Heredero G, Gómez de Las Heras MM, Escrig-Larena JI, Mittelbrunn M.Annu Rev Immunol. 2023 Apr 26;41:181-205. doi: 10.1146/annurev-immunol-101721-064501.PMID: 37126417 
  3. The role of T cells in age-related diseases.
    Carrasco E, Gómez de Las Heras MM, Gabandé-Rodríguez E, Desdín-Micó G, Aranda JF, Mittelbrunn M. Nat Rev Immunol. 2022 Feb;22(2):97-111. doi: 10.1038/s41577-021-00557-4. Epub 2021 Jun 7.PMID: 34099898 
  4. Hallmarks of T cell aging.
    Mittelbrunn M, Kroemer G.Nat Immunol. 2021 Jun;22(6):687-698. doi: 10.1038/s41590-021-00927-z. Epub 2021 May 13.PMID: 33986548
  5. Extracellular Tuning of Mitochondrial Respiration Leads to Aortic Aneurysm.
    Oller J, Gabandé-Rodríguez E, Ruiz-Rodríguez MJ, Desdín-Micó G, Aranda JF, Rodrigues-Diez R, Ballesteros-Martínez C, Blanco EM, Roldan-Montero R, Acuña P, Forteza Gil A, Martín-López CE, Nistal JF, Lino Cardenas CL, Lindsay ME, Martín-Ventura JL, Briones AM, Redondo JM, Mittelbrunn M. Circulation. 2021 May 25;143(21):2091-2109. doi: 10.1161/CIRCULATIONAHA.120.051171. Epub 2021 Mar 12.PMID: 33709773
  6.  T cells with dysfunctional mitochondria induce multimorbidity and premature senescence.
    Desdín-Micó G, Soto-Heredero G, Aranda JF, Oller J, Carrasco E, Gabandé-Rodríguez E, Blanco EM, Alfranca A, Cussó L, Desco M, Ibañez B, Gortazar AR, Fernández-Marcos P, Navarro MN, Hernaez B, Alcamí A, Baixauli F, Mittelbrunn M. Science. 2020 Jun 19;368(6497):1371-1376. doi: 10.1126/science.aax0860. Epub 2020 May 21.PMID: 32439659
  7. Mitochondrial Respiration Controls Lysosomal Function during Inflammatory T Cell Responses.
    Baixauli F, Acín-Pérez R, Villarroya-Beltrí C, Mazzeo C, Nuñez-Andrade N, Gabandé-Rodriguez E, Ledesma MD, Blázquez A, Martin MA, Falcón-Pérez JM, Redondo JM, Enríquez JA, Mittelbrunn M. Cell Metab. 2015 Sep 1;22(3):485-98. doi: 10.1016/j.cmet.2015.07.020. Epub 2015 Aug 20.PMID: 26299452