Overview
Jianwen Que, MD, PhD is an Associate Professor of Medicine at Columbia University Medical Center (CUMC). His research is focused on the role of stem/progenitor cells in homeostasis and disease pathogenesis in gastrointestinal organs including esophagus, stomach etc. He is the Faculty Director of the Genetically Modified Mouse Models Shared Resource (GMMSR) at the Herbert Irving Comprehensive Cancer Center (HICCC) and Director of the Columbia Center for Human Development at Columbia University. Dr. Que is a member of several national organizations and societies, including the American Gastroenterological Association and The American Society for Clinical Investigation (ASCI), and serves as Editor-in-Chief of the Journal of Respiratory Biology and Translational Medicine. He received his PhD from the National University of Singapore in the Department of Surgery and his MD from Peking University.
Academic Appointments
- Associate Professor of Medicine, Department of Medicine
Administrative Titles
- Director, Columbia Center for Human Development
- Faculty Director, Genetically Modified Mouse Models Shared Resource, HICCC
Credentials & Experience
Education & Training
- MD, Health Science Center, Peking University, Beijing, China
- PhD, Department of Surgery, National University of Singapore
- Postdoctoral Fellowship, Duke University
Committees, Societies, Councils
- Member, The LungMAP2 external advisory committee (NIH)
- Member, International Society for Diseases of the Esophagus
- Member, American Gastroenterological Association
- Member, The American Society for Clinical Investigation (ASCI)
- Member, Society for Developmental Biology (SDB)
- Editor-in-Chief Journal of Respiratory Biology and Translational Medicine
- Review Editor, Frontiers in Cell and Developmental Biology
Honors & Awards
| 2024 2023 2022 2022 2021 |
Elected member of The Association of American Physicians (AAP) Irene and Arthur Fishberg Award (2023), Columbia University CALA (Chinese-American Lung Association) Established Investigator Award (2022) Elected organizer of FASEB meeting: Lung epithelium in development and disease (2024) Elected organizer of FASEB meeting: Lung epithelium in development and disease (2022) |
| 2018 | Elected organizer of FASEB meeting: Lung epithelium in development and disease (2020) |
| 2018 | Elected member of The American Society for Clinical Investigation (ASCI) |
| 2014 | NYSTEM IDEA Award (New York State Stem Cell Science) |
| 2012 | March of Dimes Basil O’Connor Starter Scholar Research Award |
| 2011 | Travel Award, FASEB Gut Stem Cell Conference at Colorado |
| 2010 | NIH Pathway to Independence Award (K99/R00), NIDDK |
| 2009 | Best Postdoctoral Fellow Presentation Award, Society for Developmental Biology |
| 2003 2001-2004 |
National University of Singapore-National University Hospital Young Scientist Award (Merit) National University of Singapore Scholarship |
Research
The Que Lab is focused on the developmental and stem cell biology of the foregut-derived organs including the esophagus and lung. The Que laboratory is the first in the world to derive the esophageal epithelium from human pluripotent stem cells (hPSCs). They further showed that hPSCs-derived esophageal cells are able to form tubular structures which have the potential for using in clinics. The incidence of esophageal adenocarcinoma has increased by seven folds for past three decades, and most of the patients need esophagectomy to remove all or parts of the esophagus. The technology developed in the Que laboratory holds the promise to generate transplantable esophagus.
Research Interests:
Lung cancer initiation; Lung development and regeneration; Upper GI cancer initiation and progression; Esophageal stem cell in maintenance and disease; Gastric stem cells in tissue maintenance and disease.Selected Publications
- Wang Z, Fang Y, Liu Z, Hao N, Zhang HH, Sun X, Que J*, Ding H*. Adapting Nanopore Sequencing Basecalling Models for Modification Detection via Incremental Learning and Anomaly Detection. Nature Communications, (accepted) (bioRxiv 2023 Dec 20:2023.12.19.572449. doi: 10.1101/2023.12.19.572449. Preprint. PMID: 38187611). *Co-corresponding author.
- Zhang Y, Karagiannis D, Liu H, Lin M, Fang Y, Jiang M, Chen X, Suresh S, Huang H, She J, Shi F, Yang P, El-Rifai W, Zaika A, Oro AE, Rustgi AK, Wang TC, Lu C, Que J. Epigenetic regulation of p63 blocks squamous-to-neuroendocrine transdifferentiation in esophageal development and malignancy. Science Advances, bioRxiv. 2023 Sep 11:2023.09.09.556982. doi: 10.1101/2023.09.09.556982. Preprint. PMID: 37745439
- Chen Q, Weng K, Lin M, Jiang M, Fang Y, Chung SSW, Huang X, Zhong Q, Liu Z, Huang Z, Lin J, Li P, El-Rifai W, Zaika A, Li H, Rustgi AK, Nakagawa H, Abrams JA, Wang TC, Lu C, Huang C, Que J. SOX9 Modulates the Transformation of Gastric Stem Cells Through Biased Symmetric Cell Division. Gastroenterology. 2023 Feb 4:S0016-5085(23)00109-9. doi: 10.1053/j.gastro.2023.01.037. Online ahead of print. PMID: 36740200
- Melms JC, Biermann J, Huang H, Wang Y, Nair A, Tagore S, Katsyv I, Rendeiro AF, Amin AD, Schapiro D, Frangieh CJ, Luoma AM, Filliol A, Fang Y, Ravichandran H, Clausi MG, Alba GA, Rogava M, Chen SW, Ho P, Montoro DT, Kornberg AE, Han AS, Bakhoum MF, Anandasabapathy N, Suárez-Fariñas M, Bakhoum SF, Bram Y, Borczuk A, Guo XV, Lefkowitch JH, Marboe C, Lagana SM, Del Portillo A, Tsai EJ, Zorn E, Markowitz GS, Schwabe RF, Schwartz RE, Elemento O, Saqi A, Hibshoosh H, Que J*, Izar B*. A molecular single-cell lung atlas of lethal COVID-19. Nature. 2021 Jul;595(7865):114-119. doi: 10.1038/s41586-021-03569-1. Epub 2021 Apr 29. PMID: 33915568. *Co-corresponding author.
For a complete list of publications, please visit PubMed.gov