Jianlong Wang, PhD

  • Professor of Medical Sciences (in Medicine)
Profile Headshot

Overview

Dr. Jianlong Wang is a Professor of Medical Sciences in Medicine at Columbia University Irving Medical Center (CUIMC) and a member of the Tumor Biology and Microenvironment research program at the Herbert Irving Comprehensive Cancer Center (HICCC). He received his Ph.D. in Biochemistry and Molecular Biology from the University of Massachusetts at Amherst and the Institute of Microbiology, Chinese Academy of Sciences, and holds an M.S. in Molecular Virology.

Joining CUIMC in 2019, Dr. Wang's research explores the molecular mechanisms underlying embryonic and cancer stemness, focusing on pluripotency-associated factors such as Tet1/2 and Zfp281/ZNF281. His lab leverages genomic and proteomic methods alongside cellular and mouse models to study the complex regulatory systems—transcriptional, post-transcriptional, translational, and post-translational—that dictate cell fate and reprogramming, contributing to insights into leukemogenesis, breast cancer metastasis, and other oncogenic processes.

Academic Appointments

  • Professor of Medical Sciences (in Medicine)

Languages

  • English
  • Mandarin

Gender

  • Male

Credentials & Experience

Honors & Awards

  • 2007: Cell Development Award from the Harvard Stem Cell Institute (HSCI)
  • 2013: The Dr. Harold and Golden Lamport Research Award
  • 2013-2017: Irma T. Hirschl and Weill-Caulier Trusts Career Scientist Award

Research

I have a broad background in stem cell and developmental biology with specific training and expertise in key research areas such as gene regulation and proteomic studies in pluripotent and cancer cells. My lab research includes transcriptional and epigenetic regulation of stem cell pluripotency and cellular reprogramming. We have also established a robust research program studying post-transcriptional regulation in stem cell and developmental biology. My lab research has laid the groundwork in studying protein interaction networks and transcriptional regulatory networks in pluripotent cells and dissecting molecular mechanisms underlying the establishment and maintenance of pluripotency.

Research Interest:

  • Pluripotency
  • Totipotency
  • Spermatogenesis
  • Embryogenesis
  • Embryonic/somatic stem cells
  • Transcriptional complexes
  • Translational control