Ann E McDermott, PhD

  • Esther and Ronald Breslow Professor of Biological Chemistry
  • Professor of Biological Sciences and Chemical Engineering

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Overview

Ann McDermott, PhD, is a Ronald and Esther Breslow Professor of Biological Chemistry at Columbia University. She holds a BSc from Harvey Mudd College and a PhD from UC Berkeley's College of Chemistry, where she trained under Kenneth Sauer and Melvin Klein. Her postgraduate training was at the Massachusetts Institute of Technology (MIT). She has held various prominent roles, including Associate Dean for Scientific Initiatives and Chair of Chemistry at Columbia University.

Academic Appointments

  • Esther and Ronald Breslow Professor of Biological Chemistry
  • Professor of Biological Sciences and Chemical Engineering

Credentials & Experience

Education & Training

  • BSc, 1981 Harvey Mudd College
  • PhD, 1988 Chemistry, University of California, Berkeley
  • Fellowship: Massachusetts Institute of Technology

Committees, Societies, Councils

  • Member, American Academy of Arts and Sciences
  • Member, National Academy of Sciences
  • Previous Member, Board of Trustees for Harvey Mudd College
  • Previous Member, Board of Directors for the New York Structural Biology Center
  • Previous Scientific Advisory Board Member, Brookhaven National Laboratories

Honors & Awards

  • Pure Award in Chemistry
  • Eastern Analytic Symposium Award for Achievement in Magnetic Resonance
  • Günther Laukien Prize in Development and Advances in Solid State NMR

Research

Dr. McDermott's research through the McDermott lab employs advanced nuclear magnetic resonance (NMR) techniques to investigate the structure, function, and conformational dynamics of proteins within their natural settings. Her research has revealed that solid-state NMR spectra of proteins, including membrane proteins in native lipid bilayers and protein assemblies like viral coats, offer detailed structural insights and dynamic property characterizations. Her work delves into the connection between enzymatic function and protein conformational changes, highlighting active site loop motions and substrate repositioning in various instances.

Selected Publications

  1. Bhate M.P. and McDermott A. (2012) Protonation state of E71 in KcsA and its role for channel collapse and inactivation. PNAS, 109, 15265-15270.
  2. Li, Jixi; McQuade, Thomas; Siemer, Ansgar B.; Napetschnig, Johanna; Moriwaki, Kenta; Hsiao, Yu-Shan; Damko, Ermelinda; Moquin, David; Walz, Thomas; McDermott, Ann; Chan, Francis Ka-Ming & Wu, Hao. (2012) The RIP1/RIP3 Necrosome Forms A Functional Amyloid Signaling Complex Required for Programmed Necrosis. Cell 150, 339-350.
  3. Raveendra, Bindu L.; Siemer, Ansgar B.; Puthanveettil, Sathyanarayanan V.; Hendrickson, Wayne A.; Kandel, Eric R. & McDermott, Ann E. (2013) Characterization of prion-like conformational changes of the neuronal isoform of Aplysia CPEB. Nature Structural & Molecular Biology, 20, 495-501.
  4. Wylie, Benjamin J.; Bhate, Manasi P.; & McDermott, Ann E. (2014) Allostery and Channel Inactivation: Global Effects of K+ Binding on KcsA in Hydrated Bilayers. Proc. Natl. Acad. Sci. v 111, p 185-190.
  5. Sergeyev, Ivan V. & McDermott, Ann E. (2014) Studies of Water Populations in Pf1 Bacteriophage by NMR. J. Chem. Phys. 141(22) 22D533
  6. Wylie, Benjamin J., Dzikovski, B, Pawsey, S., Caporini, M., Rosay, M., Freed, J., & McDermott, Ann E. (2015) Dynamic Nuclear Polarization of Membrane Proteins Using Covalently Bound Radicals. Journal of Biomlecular NMR, volume 61, p 361-3
  7. Laage, Ségolène, Tao, Yisong and McDermott, Ann E. (2015) Cardiolipin Interaction with Subunit c of ATP Synthase: Solid-state NMR Characterization, Biophys Biochem A v 1848 260-265.
  8. Miguel Mompeán, Rubén Hervás, Yunyao Xu, Timothy H. Tran, Corrado Guarnaccia, Emanuele Buratti, Francisco Baralle, Liang Tong, Mariano Carrión-Vázquez, Ann E. McDermott, and Douglas V. Laurents (2015) Structural Evidence of Amyloid Fibril Formation in the Putative Aggregation Domain of TDP-43 J. Phys. Chem. Lett.,  6 (13), pp 2608–2615.
  9. Harris MJ, Struppe JO, Wylie BJ, McDermott AE, Thompson LK. (2016) Multidimensional Solid-State Nuclear Magnetic Resonance of a Functional Multiprotein Chemoreceptor Array. Biochemistry 55(26):3616-24.
  10. Rogawski, Rivkah; Sergeyev, Ivan V.; Li, Yongjun; Ottaviani, M. Francesca; Cornish, Virginia W.; McDermott, Ann E. (2016) Dynamic Nuclear Polarization Signal Enhancement with High-Affinity Biradical Tags, Journal of Physical Chemistry B, 121 (6), 1169-1175.
  11. Sergeyev, Ivan V.; Itin, Boris; Rogawski, Rivkah; Day, Loren A.; McDermott, Ann E. (2017) Efficient Assignment and NMR Analysis of an Intact Virus Using Sequential Sidechain Correlations and DNP Sensitization, PNAS 114 (20), 5171-5176.
  12. Xu, Yunyao; Bhate, Manasi P.; McDermott, Ann E. (2017) Transmembrane Allosteric Energetics: Strong coupling between protons and potassium ions binding in the KcsA channel, PNAS 114 (33) 8788-8793.
  13. Rogawski, Rivkah; McDermott, Ann E. (2017) New NMR Tools for Protein Structure and Function: Spin Tags for Dynamic Nuclear Polarization Solid State NMR. Arch Biochem. Biophys. 628 102-113.
  14. Rogawski, Rivkah; Sergeyev, Ivan V.; Li, Yongjun; Tong, Liang; McDermott, Ann E. (2017) NMR Signal Quenching from Bound Biradical Affinity Reagents in DNP, Journal of Physical Chemistry, in press.
  15. Fritzsching, K.; Itin, B.; and McDermott, A. (2017) N,N-Diethylmethylamine as lineshape standard for NMR above 130 K, JMR, in press.
  16. McDermott, Ann E. (Ed.), Polenova, Tatyana (Ed.) Solid State NMR Studies of Biopolymers. West Sussex, UK: John Wiley & Sons, 2010. ISBN: 978-0-470-72122-3
  17. Fritzsching, Keith. J.; Itin, B.; and McDermott, Ann E. (2018) “N,N-Diethylmethylamine as lineshape standard for NMR above 130 K” Journal of Magnetic Resonance 287 :110- 112.
  18. Mompea?n, Miguel; Li, Wenbo; Li, Jixi; Laage, Se?gole?ne; Siemer, Ansgar. B. Bozkurt, Gunes, Wu, Hao. and McDermott, Ann E. (2018) “The Structure of the Necrosome RIPK1- RIPK3 core, a human hetero-amyloid signaling complex”. Cell 173:1244-125.
  19. Wu, H.; Bozkurt, G.; McDermott, A; and Momeapn, M. (2018) A Closer Look at RIPK1-RIPK3 Core Amyloids, Science Trends
  20. Keeler, Eric. G; Fritzsching, Keith. J.; and McDermott, Ann E.(2018) “Refocusing CSA during magic angle spinning rotating-frame relaxation experiments” Journal of Magnetic Resonance.
  21. Xu, Yunyao; Zhang, Dongyu; Rogwaski Rivkah; Nimigean, Crina M.; McDermott, Ann E (2018) Coupled Clusters of Allostery Participants : Identification by Chemical Shift, submitted PNAS.

For a complete list of publications, please visit PubMed.gov