Joel T. Gabre, MD
Overview
Areas of Expertise / Conditions Treated
- Cancer Genetics
- Celiac Disease
- Familial Adenomatous Polyposis (FAP)
- Gastrointestinal Cancer
- Genetic Screening
- Hereditary Nonpolyposis Colorectal Cancer (HNPCC)
- Peutz-Jeghers Syndrome
- Sessile Serrated Polypsis Syndrome
- Virtual Colonoscopy
Academic Appointments
- Assistant Professor of Medicine at CUIMC
Hospital Affiliations
- NewYork-Presbyterian / Columbia University Irving Medical Center
Gender
- Male
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Phone Appointments
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Location(s)
Insurance Accepted
Aetna
- Aetna Signature Administrators
- NYP Employee Plan
- NY Signature
- POS
- Student Health
Affinity Health Plan
- Essential Plan
- Medicaid Managed Care
AgeWell
- Medicare Managed Care
- Special Needs
Amerigroup of New Jersey
- New Jersey Services (Medicaid Managed Care)
Amida Care
- Special Needs
Cigna
- EPO
- Great West (National)
- HMO
- Medicare Managed Care
- POS
- PPO
Emblem/GHI
- Medicare Managed Care
- PPO
Emblem/HIP
- ConnectiCare
- EPO
- Essential Plan
- HMO
- Medicare Managed Care
- POS
- PPO
- Select Care (Exchange)
- Vytra
Empire Blue Cross/Blue Shield
- EPO
- HMO
- PPO
Empire Blue Cross Blue Shield HealthPlus
- Child/Family Health Plus
- Essential Plan
Fidelis Care
- Child/Family Health Plus
- Essential Plan
- Medicaid Managed Care
- Medicare Managed Care
Healthfirst
- Child/Family Health Plus
- Leaf (Exchange)
- Medicare Managed Care
Local 1199
- Local 1199
MagnaCare (National)
- MagnaCare
Medicare
- Railroad
- Traditional Medicare
Multiplan
- Multiplan
MVP Health Care
- Child/Family Health Plus
- Essential Plan
- HMO
- Medicaid Managed Care
Quality Health Management
- Quality Health Management
RiverSpring
- Special Needs
UnitedHealthcare
- Compass (Exchange)
- Empire Plan
- HMO
- Medicaid (Community Plan)
- Oxford Freedom
- Oxford HMO
- Oxford Liberty
- POS
- PPO
VNSNY CHOICE
- SelectHealth
WellCare
- Medicare Managed Care
World Trade Center Health Plan
- World Trade Center Health Plan
Credentials & Experience
Education & Training
- University of Maryland School of Medicine
- Residency: Central Michigan University
- Fellowship: The University of Pennsylvania
Board Certifications
- Internal Medicine
Research
I use novel 3D organoid cultures to study esophageal development and esophageal adenocarcinoma. I first became interested in the molecular basis of gastrointestinal malignancies as a resident physician in the lab of Yana Zavros, PhD at the University of Cincinnati where I learned advanced 3D cell culture techniques to model gastric metaplasia and gastric carcinogenesis. I also introduced and helped develop a protocol to use patient-derived 3D gastric cancer organoids for personalized medicine. Given this interest and experience in metaplasia and 3D organoid cultures, I joined the lab of Dr. Anil K. Rustgi, Director of the Herbert Irving Comprehensive Cancer Center (HICCC) at Columbia University.
I have focused on using 3D esophageal organoids to study mechanisms of cellular plasticity and trans-differentiation. In particular, I seek to understand conserved developmental pathways re-activated during metaplasia using human induced pluripotent stem cell (iPSC) derived esophageal organoids. I have also continued to use patient-derived organoids from patients with esophageal adenocarcinoma for personalized medicine.
I have been recruited to join Dr. Rustgi as an Instructor of Medicine in the Division of Digestive and Liver Diseases at Columbia while I continue as a trainee in his laboratory. The unique opportunities for collaboration with investigators in related domains of esophageal epithelial biology at Columbia make it an ideal environment for my interests in metaplasia and 3D organoid cultures for personalized medicine.
Selected Publications
Mukhopadhyay S, Gabre J, Chabasse C, Bromberg JS, Antalis TM, Sarkar R. Int J Mol Sci 2020 21(5). pii: E1650. doi: 10.3390/ijms21051650. PMID: 32121269
Bertaux-Skeirik N, Wunderlich M, Teal E, Chakrabarti J, Biesiada J, Mahe M, Sundaram N, Gabre J, Hawkins J, Jian G, Engevik AC, Yang L, Wang J, Goldenring JR, Qualls JE, Medvedovic M, Helmrath MA, Diwan T, Mulloy JC, Zavros Y. CD44 variant isoform 9 emerges in response to injury and contributes to the regeneration of the gastric epithelium. J Pathol. 2017 Aug;242(4):463-475. doi: 10.1002/path.4918. PMID: 28497484
Bertaux-Skeirik N, Centeno J, Gao J, Gabre J, Zavros Y. Oncogenic transformation of human-derived gastric organoids. Methods Mol Biol. 2019; 1576:205-213. doi: 10.1007/7651_2016_4. PMID: 27539460
For a complete list of publications, please visit PubMed.gov