Institute for Cancer Genetics

Recent Publications

  1. CHD2 Regulates Neuron-Glioma Interactions in Pediatric Glioma (link is external and opens in a new window)
    Zhang X, Duan S, Apostolou PE, Wu X, Watanabe J, Gallitto M, Barron T, Taylor KR, Woo PJ, Hua X, Zhou H, Wei HJ, McQuillan N, Kang KD, Friedman GK, Canoll PD, Chang K, Wu CC, Hashizume R, Vakoc CR, Monje M, McKhann GM, Gogos JA, Zhang Z
    Cancer Discov. 2024.
     
  2. PHLDA2 is critical for p53-mediated ferroptosis and tumor suppression (link is external and opens in a new window)
    Yang X, Gu W
    J Mol Cell Biol. 2024.
     
  3. Design, Synthesis, and Evaluation of p53Y220C Acetylation Targeting Chimeras (AceTACs) (link is external and opens in a new window)
    Hu X, Kabir M, Lin Y, Xiong Y, Parsons RE, Gu W, Jin J
    J Med Chem. 2024.
     
  4. MEF2B C-terminal mutations enhance transcriptional activity and stability to drive B cell lymphomagenesis (link is external and opens in a new window)
    Yu C, Shen Q, Holmes AB, Mo T, Tosato A, Soni RK, Corinaldesi C, Koul S, Pasqualucci L, Hussein S, Forouhar F, Dalla-Favera R, Basso K
    Nat Commun. 2024.
     
  5. FLT1 activation in cancer cells promotes PARP-inhibitor resistance in breast cancer (link is external and opens in a new window)
    Tai Y, Chow A, Han S, Coker C, Ma W, Gu Y, Estrada Navarro V, Kandpal M, Hibshoosh H, Kalinsky K, Manova-Todorova K, Safonov A, Walsh EM, Robson M, Norton L, Baer R, Merghoub T, Biswas AK, Acharyya S
    EMBO Mol Med. 2024.
     
  6. The dynamics and regulation of PARP1 and PARP2 in response to DNA damage and during replication (link is external and opens in a new window)
    Zhang H, Zha S
    DNA Repair (Amst). 2024.
     
  7. Mrc1 regulates parental histone segregation and heterochromatin inheritance (link is external and opens in a new window)
    Toda T, Fang Y, Shan CM, Hua X, Kim JK, Tang LC, Jovanovic M, Tong L, Qiao F, Zhang Z, Jia S
    Mol Cell. 2024.
     
  8. Tumor detection by analysis of both symmetric- and hemi-methylation of plasma cell-free DNA (link is external and opens in a new window)
    Hua X, Zhou H, Wu HC, Furnari J, Kotidis CP, Rabadan R, Genkinger JM, Bruce JN, Canoll P, Santella RM, Zhang Z
    Nat Commun. 2024.
     
  9. Replication-Independent ICL Repair: From Chemotherapy to Cell Homeostasis (link is external and opens in a new window)
    Ahmed A, Kato N, Gautier J
    J Mol Biol. 2024.
     
  10. Romidepsin and Afatinib Abrogate Jak-Signal Transducer and Activator of Transcription Signaling and Elicit Synergistic Antitumor Effects in Cutaneous T-Cell Lymphoma (link is external and opens in a new window)
    Shih BB, Ma C, Cortes JR, Reglero C, Miller H, Quinn SA, Albero R, Laurent AP, Mackey A, Ferrando AA, Geskin L, Palomero T
    J Invest Dermatol. 2024.
     
  11. Understanding the complexity of p53 in a new era of tumor suppression (link is external and opens in a new window)
    Liu Y, Su Z, Tavana O, Gu W
    Cancer Cell. 2024.
     
  12. An unexpected role for the ketogenic diet in triggering tumor metastasis by modulating BACH1-mediated transcription (link is external and opens in a new window)
    Su Z, Liu Y, Xia Z, Rustgi AK, Gu W
    Sci Adv. 2024.
     
  13. The PCNA-Pol δ complex couples lagging strand DNA synthesis to parental histone transfer for epigenetic inheritance (link is external and opens in a new window)
    Serra-Cardona A, Hua X, McNutt SW, Zhou H, Toda T, Jia S, Chu F, Zhang Z
    Sci Adv. 2024.
     
  14. Structure of a histone hexamer bound by the chaperone domains of SPT16 and MCM2 (link is external and opens in a new window)
    Gan S, Yang WS, Wei L, Zhang Z, Xu RM
    Sci China Life Sci. 2024.
     
  15. TARGET: A phase I/II open-label multicenter study to assess safety and efficacy of fexagratinib in patients with relapsed/refractory FGFR fusion-positive glioma (link is external and opens in a new window)
    Picca A, Di Stefano AL, Savatovsky J, Ducray F, Chinot O, Moyal EC, Augereau P, Le Rhun E, Schmitt Y, Rousseaux N, Yepnang AMM, Estellat C, Charbonneau F, Letourneur Q, Branger DF, Meyronet D, Fardeau C, Mokhtari K, Bielle F, Iavarone A, Sanson M
    Neurooncol Adv. 2024.
     
  16. Systematic analysis of proteome turnover in an organoid model of pancreatic cancer by dSILO (link is external and opens in a new window)
    Ross AB, Gorhe D, Kim JK, Hodapp S, DeVine L, Chan KM, Chio IIC, Jovanovic M, Ayres Pereira M
    Cell Rep Methods. 2024.
     
  17. RuBi-Ruxolitinib: A Photoreleasable Antitumor JAK Inhibitor (link is external and opens in a new window)
    Rafic E, Ma C, Shih BB, Miller H, Yuste R, Palomero T, Etchenique R
    J Am Chem Soc. 2024.
     
  18. Extrachromosomal telomere DNA derived from excessive strand displacements (link is external and opens in a new window)
    Lee J, Lee J, Sohn EJ, Taglialatela A, O'Sullivan RJ, Ciccia A, Min J
    Proc Natl Acad Sci USA. 2024.
     
  19. Deregulated DNA ADP-ribosylation impairs telomere replication (link is external and opens in a new window)
    Wondisford AR, Lee J, Lu R, Schuller M, Groslambert J, Bhargava R, Schamus-Haynes S, Cespedes LC, Opresko PL, Pickett HA, Min J, Ahel I, O'Sullivan RJ
    Nat Struct Mol Biol. 2024.
     
  20. Chromatin compartments at DNA double-stranded breaks (link is external and opens in a new window)
    Min J, Gautier J
    Cell Res. 2024.
     
  21. BRCA1 and 53BP1 regulate reprogramming efficiency by mediating DNA repair pathway choice at replication-associated double-strand breaks (link is external and opens in a new window)
    Georgieva D, Wang N, Taglialatela A, Jerabek S, Reczek CR, Lim PX, Sung J, Du Q, Horiguchi M, Jasin M, Ciccia A, Baer R, Egli D
    Cell Rep. 2024.
     
  22. PHLDA2-mediated phosphatidic acid peroxidation triggers a distinct ferroptotic response during tumor suppression (link is external and opens in a new window)
    Yang X, Wang Z, Samovich SN, Kapralov AA, Amoscato AA, Tyurin VA, Dar HH, Li Z, Duan S, Kon N, Chen D, Tycko B, Zhang Z, Jiang X, Bayir H, Stockwell BR, Kagan VE, Gu W
    Cell Metab. 2024.
     
  23. Atypical Fibroxanthoma Treated with a Topical Combination of Imiquimod, Tazarotene, and 5-Fluorouracil (link is external and opens in a new window)
    Nahm WJ, Badiavas EV, Kirsner RS, Boyd CJ, Arthur AA, Bae S, Shen J
    Dermatol Ther (Heidelb). 2024.
     
  24. Coordination of histone chaperones for parental histone segregation and epigenetic inheritance (link is external and opens in a new window)
    Fang Y, Hua X, Shan CM, Toda T, Qiao F, Zhang Z, Jia S
    Genes Dev. 2024.
     
  25. GAS41 modulates ferroptosis by anchoring NRF2 on chromatin (link is external and opens in a new window)
    Wang Z, Yang X, Chen D, Liu Y, Li Z, Duan S, Zhang Z, Jiang X, Stockwell BR, Gu W
    Nat Commun. 2024.
     
  26. SMARCAL1 is a dual regulator of innate immune signaling and PD-L1 expression that promotes tumor immune evasion (link is external and opens in a new window)
    Leuzzi G, Vasciaveo A, Taglialatela A, Chen X, Firestone TM, Hickman AR, Mao W, Thakar T, Vaitsiankova A, Huang JW, Cuella-Martin R, Hayward SB, Kesner JS, Ghasemzadeh A, Nambiar TS, Ho P, Rialdi A, Hebrard M, Li Y, Gao J, Gopinath S, Adeleke OA, Venters BJ, Drake CG, Baer R, Izar B, Guccione E, Keogh MC, Guerois R, Sun L, Lu C, Califano A, Ciccia A
    Cell. 2024.
     
  27. Functional Analysis of Membrane-Associated Scaffolding Tight Junction (TJ) Proteins in Tumorigenic Characteristics of B16-F10 Mouse Melanoma Cells (link is external and opens in a new window)
    Ko EJ, Kim DY, Kim MH, An H, Kim J, Jeong JY, Song KS, Cha HJ
    Int J Mol Sci. 2024.
     
  28. Transcription-Coupled Repair of DNA Interstrand Crosslinks by UVSSA (link is external and opens in a new window)
    Liebau RC, Waters C, Ahmed A, Soni RK, Gautier J
    bioRxiv. 2024.
     
  29. CRISPRmap: Sequencing-free optical pooled screens mapping multi-omic phenotypes in cells and tissue (link is external and opens in a new window)
    Gu J, Iyer A, Wesley B, Taglialatela A, Leuzzi G, Hangai S, Decker A, Gu R, Klickstein N, Shuai Y, Jankovic K, Parker-Burns L, Jin Y, Zhang JY, Hong J, Niu S, Chou J, Landau DA, Azizi E, Chan EM, Ciccia A, Gaublomme JT
    bioRxiv. 2023.
     
  30. A noncanonical IRAK4-IRAK1 pathway counters DNA damage-induced apoptosis independently of TLR/IL-1R signaling (link is external and opens in a new window)
    Li Y, Shah RB, Sarti S, Belcher AL, Lee BJ, Gorbatenko A, Nemati F, Yu H, Stanley Z, Rahman M, Shao Z, Silva JM, Zha S, Sidi S
    Sci Signal. 2023.
     

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