Fu Lab
Dr. Jianing Fu is an Assistant Professor in the Department of Medicine and a principal investigator at the Columbia Center for Translational Immunology (CCTI). Dr. Fu obtained her BS degree in Pharmaceutical Sciences and MS degree in Chemical Biology from Peking University (China) and received her PhD in Cancer Biology and Immunology from University of South Florida and H. Lee Moffitt Cancer Center. She did a Curricular Practical Training at Medical University of South Carolina to complete her doctoral education. Dr. Fu joined Columbia University in May 2015 to start her postdoctoral training and later took the lead on several projects related to human organ transplantation under the roles of Associate Research Scientist and Instructor.
At Columbia, Dr. Fu’s laboratory is conducting translational research on decoding the graft-versus-host (GvH) and host-versus-graft (HvG) alloreactivity after human intestinal transplantation and lung transplantation. Her research also extends in investigating the phenotype and function of gut and lung hematopoietic stem cells and progenitors, with the ultimate goal of eliminating graft rejection by inducing long persistent blood mixed chimerism. Dr. Fu has established long term multidisciplinary collaboration with transplant surgeons, adult and pediatric physicians, pathologists, bioinformatic scientists and translational immunologists to perform cutting edge human transplantation studies.
Lab Members
Tyla Young
- Technician
Select Publications
Wu Y, Zuber J and Fu J*. Editorial: Immunogenomics of Solid Organ and Hematopoietic Stem Cell Transplantation. Frontiers in Immunology. 2022, 13:878314. (*Corresponding author)
Fu J, Sykes M. Emerging Concepts of Tissue-Resident Memory T cells in Transplantation. Transplantation. 2022 Jun 1;106(6):1132-1142.
Obradovic A, Shen Y, Sykes M, Fu J*. Integrated Analysis Toolset for Defining and Tracking Alloreactive T-cell Clones After Human Solid Organ and Hematopoietic Stem Cell Transplantation. Software Impacts. 2021 (10) 100142 (*Corresponding author)
Fu J#, Khosravi-Maharlooei M, Sykes M. High throughput human T cell receptor sequencing: a new window into repertoire establishment and alloreactivity. Frontiers in Immunology. 2021, 12:777756. #Co-first author.
Fu J, Zuber J, Shonts B, Obradovic A, Wang Z, Frangaj K, Meng W, Rosenfeld A, Waffarn E, Liou P, Lau S-p, Savage T, Yang S, Rogers K, Danzl Nichole, Ravella S, Satwani P, Iuga A, Ho S-h, Griesemer A, Shen Y, Luning-Prak E, Martinez M, Kato T, Sykes M. Lymphohematopoietic graft-versus-host responses promote mixed chimerism in patients receiving intestinal transplantation. Journal of Clinical Investigation. 2021 Apr 15;131(8):e141698.
Fu J, Zuber J, Martinez M, Shonts B, Obradovic A, Wang H, Lau S-p, Xia A, Waffarn E, Frangaj K, Savage T, Simpson T, Yang S, Guo X, Miron M, Senda T, Rogers K, Rahman A, Ho S-h, Shen Y, Griesemer A, Farber D, Kato T, Sykes M. Human Intestinal Allografts Contain Functional Hematopoietic Stem and Progenitor Cells that are Maintained by a Circulating Pool. Cell Stem Cell. 2019 Feb 7;24(2):227-239.e8. (Commentary: “We Could Use More Tolerance: Role of Intestinal-Allograft- Derived Human Stem Cells”.)
Fu J, Wu Y, Nguyen H, Heinrichs J, Schutt S, Liu Y, Liu C, Jin J, Anasetti C, and Yu X-Z. T-bet promotes acute graft-versus-host disease by regulating recipient hematopoietic cells in mice. J Immunol. 2016 Apr 1; 196 (7): 3168-3179. Cover Article.
Fu J, Wang D, Yu Y, Heinrichs J, Wu Y, Schutt S, Kaosaard K, Liu C, Haarberg K, Bastian D, McDonald D, Anasetti C, and Yu X-Z. T-bet is critical for the development of acute graft-versus-host disease through controlling T-cell differentiation and function. J Immunol. 2015 Jan 1;194(1):388-97.
Fu J, Heinrichs J, Yu X. Helper T-cell Differentiation in Graft-versus-Host Disease after Allogeneic Hematopoietic Stem Cell Transplantation. Arch Immunol Ther Exp. 2014 Aug; 62(4): 277-301.
Long K, Fu J*. Chimerism and phenotypic analysis of intraepithelial and lamina propria T lymphocytes isolated from fresh human ileal biopsies after intestinal transplantation. STAR Protocols. 2023, 4 (2), 102192. (*Corresponding author)
Fu J*, Wang Z, Martinez M, Jiao W, Frangaj K, Jones R, Guo X, Zhang Y, Kuo W-I, Ko H, Iuga A, Obradovic A, Bay Muntnich C, Rogers K, Zuber J, Ma W, Miron M, Farber D, Kato T, Shen Y, Sykes M*. Heterogeneity and Plasticity of Alloreactive T Cells in Human Intestinal Allografts: New Insights into Tissue Residency and Immune Tolerance after Transplantation. Journal of Experimental Medicine. 2024. 221 (1): e20230930. (*Co-corresponding author)
Long K, Fu J*. Chimerism and phenotypic analysis of intraepithelial and lamina propria T lymphocytes isolated from fresh human ileal biopsies after intestinal transplantation. STAR Protocols. 2023, 4 (2), 102192. (*Corresponding author)
Crosby K, Long K and Fu J. Chimerism-Mediated Tolerance in Intestinal Transplantation. Gastroenterology Clinics of North America. 2024. Epub ahead of print. doi:10.1016/j.gtc.2023.12.009
Suek N, Young T and Fu J. Immune Cell Profiling in Intestinal Transplantation. Human Immunology. 2024 May 18:110808. doi: 10.1016/j.humimm.2024.110808. Epub ahead of print.