Cardoso Lab
Principal Investigator
Research in the Cardoso Lab focuses on the mechanisms controlling lung development, regeneration-repair and developmental signaling in lung diseases. Ongoing studies aim to elucidate the origin and regulation of differentiation of the basal stem cells in the human lung. Basal cells are a major component of the airway stem cell compartment able to self-renew and give rise to nearly all cell types present in the epithelium of conducting airways. These cells have a great potential to advance stem cell therapies as they can be readily isolated from a variety of sources from simple nasal swabs, nasopharyngeal aspirates, bronchial brushing, and biopsies. Current protocols in the lab allow expansion, genetic manipulation and differentiation of these cells in relatively large scale for potential use in bioengineering and transplantation approaches in future cell therapies.
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